Interstate 64 is an Interstate Highway in the Eastern United States. Its western terminus is at I-70, U.South. Route 40, and US 61 in Wentzville, Missouri. Its eastern terminus is at an interchange with I-264 and I-664 at Bowers Hill in Chesapeake, Virginia. I-64 connects the major metropolitan areas of St. Louis, Louisville and Lexington in Kentucky, Charleston, West Virginia, and Richmond, Virginia. At 953.74 miles, I-64 is the second longest interstate highway not ending with a 5 or 0, after I-94.